Cluster-based psychological phenotyping and differences in anxiety treatment outcomes.

ABSTRACT: The identification of markers of mental health illness treatment response and susceptibility using personalized medicine has been elusive. In the context of psychological treatment for anxiety, we conducted two studies to identify psychological phenotypes with distinct characteristics related to: psychological intervention modalities (mindfulness training/awareness), mechanism of action (worry), and clinical outcome (generalized anxiety disorder scale scores). We also examined whether phenotype membership interacted with treatment response (Study 1) and mental health illness diagnosis (Studies 1-2). Interoceptive awareness, emotional reactivity, worry, and anxiety were assessed at baseline in treatment-seeking individuals (Study 1, n = 63) and from the general population (Study 2, n = 14,0

SUBMITTER: Taylor VA 

PROVIDER: S-EPMC9944281 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature