Metabolic regulation of species-specific developmental rates.

ABSTRACT: Animals display substantial inter-species variation in the rate of embryonic development despite a broad conservation of the overall sequence of developmental events. Differences in biochemical reaction rates, including the rates of protein production and degradation, are thought to be responsible for species-specific rates of development^1-3. However, the cause of differential biochemical reaction rates between species remains unknown. Here, using pluripotent stem cells, we have established an in vitro system that recapitulates the twofold difference in developmental rate between mouse and human embryos. This system provides a quantitative measure of developmental speed as revealed by the period of the segmentation clock, a molecular oscillator associated with the rhythmic produ

SUBMITTER: Diaz-Cuadros M 

PROVIDER: S-EPMC9944513 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature