Surgery for metastatic pancreatic neuroendocrine tumors: a narrative review.

ABSTRACT:

Background and objective

Pancreatic neuroendocrine tumors (PanNETs) are derived from the islet cells of the pancreas and have been increasing in incidence. Most of these tumors are nonfunctional although some can secrete hormones and lead to hormone-specific clinical syndromes. Surgery is the mainstay of treatment for localized tumors, however, surgical resection is controversial in metastatic PanNETs. This narrative review seeks to summarize the current literature surrounding surgery, specifically in the controversial area of metastatic PanNETs, review current treatment paradigms, and understand the benefits of surgery in this group of patients.

Methods

Authors searched PubMed using the terms "surgery pancreatic neuroendocrine tumor", "metastatic neuroendocrine tumor", and

SUBMITTER: Williams JK 

PROVIDER: S-EPMC9944533 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature