Screening tools for predicting mortality of adults with suspected sepsis: an international sepsis cohort validation study.

ABSTRACT:

Objectives

We evaluated the performance of commonly used sepsis screening tools across prospective sepsis cohorts in the USA, Cambodia and Ghana.

Design

Prospective cohort studies.

Setting and participants

From 2014 to 2021, participants with two or more SIRS (Systemic Inflammatory Response Syndrome) criteria and suspected infection were enrolled in emergency departments and medical wards at hospitals in Cambodia and Ghana and hospitalised participants with suspected infection were enrolled in the USA. Cox proportional hazards regression was performed, and Harrell's C-statistic calculated to determine 28-day mortality prediction performance of the quick Sequential Organ Failure Assessment (qSOFA) score ≥2, SIRS score ≥3, National Early Warning Score (NEWS) ≥5, Modifie

SUBMITTER: Blair PW 

PROVIDER: S-EPMC9944645 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature