Association of blood lead with estradiol and sex hormone-binding globulin in 8-19-year-old children and adolescents

ABSTRACT:

Background

Metals can interfere with hormonal functioning through indirect mechanisms and by binding at the receptor site; thus, they may be associated with hormonal changes. However, there have been few studies on the health impact of metal exposure among children and adolescents. Thus, we aimed to examine the associations of blood lead level (BLL) with estradiol (E2) and sex hormone-binding globulin (SHBG) among children and adolescents aged 8–19 years in the National Health and Nutrition Examination Survey (NHANES) database.

Methods

This was a cohort study of 2188 individuals from the NHANES. BLL was taken as independent variables, E2 and SHBG as dependent variable. We conducted weighted multivariate linear regression models and smooth curve fittings to evaluate the as

SUBMITTER: Pan K 

PROVIDER: S-EPMC9944751 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature