Brachial plexus avulsion induced changes in gut microbiota promotes pain related anxiety-like behavior in mice.

ABSTRACT:

Introduction

Brachial plexus avulsion (BPA) injury develops frequent and intense neuropathic pain, involving in both peripheral and central nervous systems. The incidence of anxiety or depression caused by BPA-induced neuropathic pain is high, but the underlying mechanism remains unclear.

Methods

We established a BPA mice model and assessed its negative emotions through behavioral tests. To further explore the role of the microbiota-gut-brain axis in the unique emotional behavior after BPA, we performed intestinal fecal 16s and metabolomics assays. Psychobiotics (PB) supplementation was administered to BPA mice to check the probiotics effects on BPA-induced anxiety behaviors.

Results

Pain related anxiety-like behavior was observed at the early stage after BPA (7 days)

SUBMITTER: Zhang JL 

PROVIDER: S-EPMC9944865 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature