Uric acid and risk of pre-eclampsia: results from a large case-control study and meta-analysis of prospective studies.

ABSTRACT: To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case-control study (1365 cases of pre-eclampsia and 1886 normotensive controls) was conducted. Pre-eclampsia was defined as blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg/24 h. Sub-outcome analysis included early, intermediate, and late pre-eclampsia. Multivariable analysis for pre-eclampsia and its sub-outcomes was conducted using binary and multinomial logistic regression, respectively. Additionally, a systematic review and meta-analysis of cohort studies measuring uric acid levels < 20 weeks of gestation was performed to rule out reverse causation. There was a positive linear association between increasing uric acid levels and presence of pre-eclampsi

SUBMITTER: Colmenares-Mejia CC 

PROVIDER: S-EPMC9944921 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature