Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease.

ABSTRACT:

Importance

Numerous studies have established the association of the common APOE ε2 and APOE ε4 alleles with Alzheimer disease (AD) risk across ancestries. Studies of the interaction of these alleles with other amino acid changes on APOE in non-European ancestries are lacking and may improve ancestry-specific risk prediction.

Objective

To determine whether APOE amino acid changes specific to individuals of African ancestry modulate AD risk.

Design, setting, and participants

Case-control study including 31 929 participants and using a sequenced discovery sample (Alzheimer Disease Sequencing Project; stage 1) followed by 2 microarray imputed data sets derived from the Alzheimer Disease Genetic Consortium (stage 2, internal replication) and the Million Veteran Program (st

SUBMITTER: Le Guen Y 

PROVIDER: S-EPMC9945061 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature