Systematic review and meta-analysis of the current literature on tocilizumab in patients with refractory Takayasu arteritis.

ABSTRACT:

Objective

To present the pooled quantitative evidence of baseline characteristics and clinical outcomes of tocilizumab (TCZ) in patients with refractory Takayasu arteritis (TAK).

Methods

A comprehensive systematic review and meta-analysis was performed on all available studies retrieved from the MEDLINE, Embase, and Cochrane databases, using TCZ in patients with refractory TAK. We applied the commands metan and metaprop_one in Stata Software to pool overall estimates of continuous data and binomial data, respectively. A random-effects model was recruited for analysis.

Results

Nineteen studies with 466 patients were included in this meta-analysis. The mean age at implementation of TCZ was 34.32 years. Female sex and Numano Type V were the most prominent b

SUBMITTER: Kang L 

PROVIDER: S-EPMC9945188 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature