Welfare assessment on healthy and tumor-bearing mice after repeated ultrasound imaging.

ABSTRACT:

Introduction

Ultrasound (US) imaging enables tissue visualization in high spatial resolution with short examination times. Thus, it is often applied in preclinical research. Diagnostic US, including contrast-enhanced ultrasound (CEUS), are considered to be well tolerated by laboratory animals although no systematic study has been performed to confirm this claim. Therefore, the aim of this study was to screen for possible effects of US and CEUS examinations on welfare of healthy mice. Additionally, the potential influence of CEUS and molecular CEUS on well-being and therapy response to regorafenib was investigated in breast cancer-bearing mice.

Material and methods

40 healthy Balb/c mice were randomly assigned for examination with US or CEUS (3x/week) for four weeks. Untreate

SUBMITTER: Girbig RM 

PROVIDER: S-EPMC9945198 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature