Eight-year trajectories of malalignment progression in symptomatic knee osteoarthritis.

ABSTRACT:

Background

Although various therapies have been developed to treat malalignment in osteoarthritic knees, the pattern of malalignment progression is still unclear. This study aimed to identify homogeneous subgroups with distinct trajectories of malalignment progression in subjects with symptomatic knee osteoarthritis (KOA) and to determine corresponding risk factors.

Methods

Eight-year follow-up (from 2004 to 2012) data on 1252 participants with symptomatic KOA from the Osteoarthritis Initiative were included. Varus/valgus angle progression was characterized by group-based trajectory models. Time-varying covariates were introduced into the model to investigate how they affected trajectories. Multinomial logistic regression for trajectory group membership was applied to ascert

SUBMITTER: Li M 

PROVIDER: S-EPMC9945354 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature