PET/CT standardized uptake value and EGFR expression predicts treatment failure in nasopharyngeal carcinoma.

ABSTRACT:

Objective

This study inventively combines epidermal growth factor receptor (EGFR) expression of the primary lesion and standardized uptake value (SUV) of positron emission tomography and computed tomography (PET/CT) to predict the prognosis of nasopharyngeal carcinoma (NPC). This study aimed to evaluate the predictive efficacy of maximum standard uptake value (SUVmax) and EGFR for treatment failure in patients with NPC.

Methods

This retrospective study reviewed the results of EGFR expression and pretreatment ¹⁸F-FDG PET/CT of 313 patients with NPC. Time-dependent receiver operator characteristics was used for analyzing results and selecting the optimal cutoff values. Cox regression was used to screen out multiple risk factors. Cumulative survival rate was calculat

SUBMITTER: Fei Z 

PROVIDER: S-EPMC9945369 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature