Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.

ABSTRACT:

Background

Foetal and early childhood development contributes to the risk of adult non-communicable diseases such as hypertension and cardiovascular disease. We aimed to investigate whether kidney size at birth is associated with markers of kidney function at 7-11 years.

Methods

Foetal kidney dimensions were measured using ultrasound scans at 34 weeks gestation and used to derive kidney volume (cm³) in 1802 participants in the Born in Bradford (BiB) birth cohort. Blood and urine samples were taken from those who participated in the BiB follow-up at 7-11 years (n = 630) and analysed for serum creatinine, cystatin C, urea, and urinary albumin to creatinine ratio (ACR), protein to creatinine ratio (PCR) and retinol binding protein (RBP). Estimated glomerular filtrati

SUBMITTER: Ziauddeen N 

PROVIDER: S-EPMC9945391 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature