Systemic induction of senescence in young mice after single heterochronic blood exchange.

ABSTRACT:

Abstact

Ageing is the largest risk factor for many chronic diseases. Studies of heterochronic parabiosis, substantiated by blood exchange and old plasma dilution, show that old-age-related factors are systemically propagated and have pro-geronic effects in young mice. However, the underlying mechanisms how bloodborne factors promote ageing remain largely unknown. Here, using heterochronic blood exchange in male mice, we show that aged mouse blood induces cell and tissue senescence in young animals after one single exchange. This induction of senescence is abrogated if old animals are treated with senolytic drugs before blood exchange, therefore attenuating the pro-geronic influence of old blood on young mice. Hence, cellular senescence is neither simply a response to stress and dam

SUBMITTER: Jeon OH 

PROVIDER: S-EPMC9945470 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature