Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study.

ABSTRACT:

Background

Exposure to per- and polyfluoroalkyl substances (PFAS) is ubiquitous and has been associated with an increased risk of several cardiometabolic diseases. However, the metabolic pathways linking PFAS exposure and human disease are unclear.

Objective

We examined associations of PFAS mixtures with alterations in metabolic pathways in independent cohorts of adolescents and young adults.

Methods

Three hundred twelve overweight/obese adolescents from the Study of Latino Adolescents at Risk (SOLAR) and 137 young adults from the Southern California Children's Health Study (CHS) were included in the analysis. Plasma PFAS and the metabolome were determined using liquid-chromatography/high-resolution mass spectrometry. A metabolome-wide association study was performed

SUBMITTER: Goodrich JA 

PROVIDER: S-EPMC9945578 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature