Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease.

ABSTRACT:

Background

Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for intervention. Here, we systematically profiled associations between blood metabolites and whole-brain volume, hippocampal volume, and amyloid-β status among participants of Insight 46-the neuroscience sub-study of the National Survey of Health and Development (NSHD). We additionally explored whether key metabolites were associated with polygenic risk for Alzheimer's disease (AD).

Methods

Following quality control, levels of 1019 metabolites-detected with liquid chromatography-mass spectrometry-were available for 1740 participants at age 60-64. Metabolite data were subsequently clustered into modules of co-expressed

SUBMITTER: Green RE 

PROVIDER: S-EPMC9945600 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature