PINK1 protects against dendritic cell dysfunction during sepsis through the regulation of mitochondrial quality control.

ABSTRACT: Dendritic cell (DC) dysfunction plays a central role in sepsis-induced immunosuppression. Recent research has indicated that collective mitochondrial fragmentation contributes to the dysfunction of immune cells observed during sepsis. PTEN-induced putative kinase 1 (PINK1) has been characterized as a guide for impaired mitochondria that can keep mitochondrial homeostasis. However, its role in the function of DCs during sepsis and the related mechanisms remain obscure. In our study, we elucidated the effect of PINK1 on DC function during sepsis and its underlying mechanism of action. Cecal ligation and puncture (CLP) surgery and lipopolysaccharide (LPS) treatment were used as in vivo and in vitro sepsis models, respectively. We found that changes in mitochondrial PINK1 expression of DCs par

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9945621 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature