Evaluation of cellular water exchange in a mouse glioma model using dynamic contrast-enhanced MRI with two flip angles.

ABSTRACT: This manuscript aims to evaluate the robustness and significance of the water efflux rate constant (k_io) parameter estimated using the two flip-angle Dynamic Contrast-Enhanced (DCE) MRI approach with a murine glioblastoma model at 7 T. The repeatability of contrast kinetic parameters and k_io measurement was assessed by a test-retest experiment (n = 7). The association of k_io with cellular metabolism was investigated through DCE-MRI and FDG-PET experiments (n = 7). Tumor response to a combination therapy of bevacizumab and fluorouracil (5FU) monitored by contrast kinetic parameters and k_io (n = 10). Test-retest experiments demonstrated compartmental volume fractions (v_e and v_p) remained consistent between scans while the vasc

SUBMITTER: Kiser K 

PROVIDER: S-EPMC9945648 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature