Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration.

ABSTRACT: The key to critical bone regeneration in tissue engineering relies on an ideal bio-scaffold coated with a controlled release of growth factors. Gelatin methacrylate (GelMA) and Hyaluronic acid methacrylate (HAMA) have been a novel topic of interest in bone regeneration while introducing appropriate nano-hydroxyapatite (nHAP) to improve its mechanical properties. And the exosomes derived from human urine-derived stem cells (human ^USCEXOs) have also been reported to promote osteogenesis in tissue engineering. The present study aimed to design a new GelMA-HAMA/nHAP composite hydrogel as a drug delivery system. The ^USCEXOs were encapsulated and slow-released in the hydrogel for better osteogenesis. The characterization of the GelMA-based hydrogel showed excellent controll

SUBMITTER: Lu W 

PROVIDER: S-EPMC9945756 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature