Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c⁺ B cells.

ABSTRACT: Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth impairments. Individuals with DS are also prone to severe infections and autoimmunity including thyroiditis, type 1 diabetes, coeliac disease and alopecia areata^1,2. Here, to investigate the mechanisms underlying autoimmune susceptibility, we mapped the soluble and cellular immune landscape of individuals with DS. We found a persistent elevation of up to 22 cytokines at steady state (at levels often exceeding those in patients with acute infection) and detected basal cellular activation: chronic IL-6 signalling in CD4 T cells and a high proportion of plasmablasts and CD11c⁺Tbet^highCD21^low B cells (Tbet is also known as TBX21). This subset is known to be autoi

SUBMITTER: Malle L 

PROVIDER: S-EPMC9945839 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature