Exercise effects on glucocorticoid-induced bone loss in adults: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Due to their pronounced anti-inflammatory and immunosuppressive effects, glucocorticoids (GCs) are widely used in inflammatory conditions and organ transplants. Unfortunately, GC-induced osteoporosis is one of the most common causes of secondary osteoporosis. The aim of the present systematic review and meta-analysis was to determine the effect of exercise added to GC therapy on BMD at the lumbar spine or femoral neck in people on GC therapy.

Methods

A systematic literature search of five electronic databases included controlled trials with a duration of >6 months and at least two study arms [glucocorticoids (GCs) and GCs and exercise (GC + EX)] were conducted up to 20 September 2022. Studies involving other pharmaceutical therapies with relevant effects on bone m

SUBMITTER: Kast S 

PROVIDER: S-EPMC9945849 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature