Gut microbial dysbiosis correlates with stroke severity markers in aged rats.

ABSTRACT:

Background

An imbalanced gut microbial community, or dysbiosis, has been shown to occur following stroke. It is possible that this dysbiosis negatively impacts stroke recovery and rehabilitation. Species level resolution measurements of the gut microbiome following stroke are needed to develop and test precision interventions such as probiotic or fecal microbiota transplant therapies that target the gut microbiome. Previous studies have used 16S rRNA amplicon sequencing in young male mice to obtain broad profiling of the gut microbiome at the genus level following stroke, but further investigations will be needed with whole genome shotgun sequencing in aged rats of both sexes to obtain species level resolution in a model which will better translate to the demographics of human stro

SUBMITTER: Hammond TC 

PROVIDER: S-EPMC9945937 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature