Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarchy.

ABSTRACT: The neural circuit of the brain is organized as a hierarchy of functional units with wide-ranging connections that support information flow and functional connectivity. Studies using MRI indicate a moderate coupling between structural and functional connectivity at the system level. However, how do connections of different directions (feedforward and feedback) and regions with different excitatory and inhibitory (E/I) neurons shape the hemodynamic activity and functional connectivity over the hierarchy are unknown. Here, we used functional MRI to detect optogenetic-evoked and resting-state activities over a somatosensory pathway in the mouse brain in relation to axonal projection and E/I distribution. Using a highly sensitive ultrafast imaging, we identified extensive activation in regions

SUBMITTER: Chuang KH 

PROVIDER: S-EPMC9945945 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature