Antibodies of the immunoglobulin a isotype to novel antigens in early axial spondyloarthritis.

ABSTRACT:

Introduction

There is an unmet need for biomarkers to identify patients with axial spondyloarthritis (axSpA). Increasing evidence suggest the presence of autoantibodies in a subset of axSpA patients. The aim of this study was to identify novel IgA antibodies in early axSpA patients and to determine their diagnostic potential in combination with previously determined IgG antibodies against UH (Hasselt University)-axSpA-IgG antigens.

Methods

An axSpA cDNA phage display library constructed from axSpA hip synovium, was used to screen for novel IgA antibodies in plasma from early axSpA patients. The presence of these antibodies against novel UH-axSpA-IgA antigens was determined in two independent axSpA cohorts, in healthy controls and in patients with chronic low back pain.

Re

SUBMITTER: Ruytinx P 

PROVIDER: S-EPMC9945964 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature