METTL3 is essential for normal progesterone signaling during embryo implantation via m⁶A-mediated translation control of progesterone receptor.

ABSTRACT: Embryo implantation, a crucial step in human reproduction, is tightly controlled by estrogen and progesterone (P₄) via estrogen receptor alpha and progesterone receptor (PGR), respectively. Here, we report that N⁶-methyladenosine (m⁶A), the most abundant mRNA modification in eukaryotes, plays an essential role in embryo implantation through the maintenance of P₄ signaling. Conditional deletion of methyltransferase-like 3 (Mettl3), encoding the m⁶A writer METTL3, in the female reproductive tract using a Cre mouse line with Pgr promoter (Pgr-Cre) resulted in complete implantation failure due to pre-implantation embryo loss and defective uterine receptivity. Moreover, the uterus of Mettl3 null mice faile

SUBMITTER: Zheng ZH 

PROVIDER: S-EPMC9945998 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature