Progestogens for maintenance tocolysis in symptomatic women. A systematic review and meta-analysis.

ABSTRACT:

Objective

Prevention of preterm birth (PTB) with progestogens after an episode of threatened preterm labour is still controversial. As different progestogens have distinct molecular structures and biological effects, we conducted a systematic review and pairwise meta-analysis to investigate the individual role played by 17-alpha-hydroxyprogesterone caproate (17-HP), vaginal progesterone (Vaginal P) and oral progesterone (Oral P).

Methods

The search was performed in MEDLINE, ClinicalTrials.gov and the Cochrane Central Register of Controlled Trials (CENTRAL) up to 31 October 2021. Published RCTs comparing progestogens to placebo or no treatment for maintenance tocolysis were considered. We included women with singleton gestations, excluding quasi-randomized trials, studies on

SUBMITTER: Ferrari F 

PROVIDER: S-EPMC9946203 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature