IPRESTO: Automated discovery of biosynthetic sub-clusters linked to specific natural product substructures.

ABSTRACT: Microbial specialised metabolism is full of valuable natural products that are applied clinically, agriculturally, and industrially. The genes that encode their biosynthesis are often physically clustered on the genome in biosynthetic gene clusters (BGCs). Many BGCs consist of multiple groups of co-evolving genes called sub-clusters that are responsible for the biosynthesis of a specific chemical moiety in a natural product. Sub-clusters therefore provide an important link between the structures of a natural product and its BGC, which can be leveraged for predicting natural product structures from sequence, as well as for linking chemical structures and metabolomics-derived mass features to BGCs. While some initial computational methodologies have been devised for sub-cluster detection, cu

SUBMITTER: Louwen JJR 

PROVIDER: S-EPMC9946207 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature