Diagnostic significance of microRNAs in sepsis.

ABSTRACT:

Background

Sepsis is a life-threatening condition that induce tens of million death each year, yet early diagnosis remains a formidable challenge. Many studies have focused on the diagnostic accuracy of microRNAs (miRNAs) for sepsis in recent years, particularly miR-155-5p, miR-21, miR-223-3p, miR-146a, and miR-125a. Thus, we conducted this meta-analysis to explore if miRNAs may be used as a biomarker for sepsis detection.

Methods

We searched PubMed, the Cochrane Central Register of Controlled Trials, EMBASE, and China National Knowledge Infrastructure through May 12, 2022. This meta-analysis was conducted using Meta-disc 1.4 and STATA 15.1 in a fixed/random-effect model.

Results

The analysis included a total of 50 relevant studies. The overall performance of total mi

SUBMITTER: Zheng X 

PROVIDER: S-EPMC9946237 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature