Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability.

ABSTRACT: The nearly insurmountable adversity that accompanies opioid use disorder (OUD) creates life-altering complications for opioid users. To worsen matters, existing small-molecule drugs continue to inadequately address OUD due to their engagement of the opioid receptor, which can leave the user to deal with side effects and financial hardships from their repeated use. An alternative therapeutic approach utilizes endogenously generated antibodies through active vaccination to reduce the effect of opioids without modulating the opioid receptor. Here, we explore different adjuvants and storage conditions to improve opioid vaccine efficacy and shelf life. Our results revealed that inulin-based formulations (Advax) containing a CpG oligodeoxynucleotide (ODN) acted as effective adjuvants when combin

SUBMITTER: Blake S 

PROVIDER: S-EPMC9946458 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature