Monkeypox virus (MPXV) genomics: A mutational and phylogenomic analyses of B.1 lineages.

ABSTRACT: The recent increase in monkeypox (MPX) cases has attracted attention of public health authorities due to its quick spread and transmission across non-endemic regions. This outbreak, unlike previous ones, displays different epidemiological features and transmission dynamics, which appear to be largely influenced by the newly divergent MPX lineages (B.1). Yet, the genomic characteristics driving the high dispersal and diversification of these lineages remain largely unknown. Herein, we sought to explore and characterize the genomic features and phylogenetic diversity of the B.1 lineages through a comparative genomic analysis inclusive of 1900 high quality complete MPXV genomes. Our analyses indicate that the current MPXV-2022 outbreak encompasses thirteen derived lineages with ten unique non

SUBMITTER: Luna N 

PROVIDER: S-EPMC9946793 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature