Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19.

ABSTRACT:

Background

Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut microbiota and mortality are scarce.

Methods

Rectal swabs for gut microbiota analyses were collected within 48 h after hospital admission (baseline; n = 123) and three-month post-admission (n = 50) in a subset of patients included in the Norwegian SARS-CoV2 cohort study. Samples were analysed by sequencing the 16S rRNA gene. Gut microbiota diversity and composition at baseline were assessed in relation to need for intensive care unit (ICU) admission during hospitalization. The primary objective was to investigate whether the ICU-related gut microbiota was associa

SUBMITTER: Troseid M 

PROVIDER: S-EPMC9946863 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature