A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice.

ABSTRACT: Dendritic cells (DCs), which are typical antigen-presenting cells, localize to various sites in the body, particularly the front line of infection as sentinels, and are involved in innate and adaptive immune responses. Although the functions of DCs, such as pathogen-induced cytokine production and antigen-specific T cell activation, are important for host defenses against infection and tumorigenesis, the hyper- and/or extended activation of DCs leads to inflammatory and autoimmune diseases. In the present study, β-damascone, a major ingredient of rose fragrance, was selected from an aroma library as a candidate compound that suppresses antigen-induced immune responses. β-Damascone inhibited the functions of DCs, including the antigen-dependent proliferation of T cells, DC-induced Th1 devel

SUBMITTER: Kodama N 

PROVIDER: S-EPMC9946980 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature