APOC-III: a Gatekeeper in Controlling Triglyceride Metabolism.

ABSTRACT:

Purpose of review

Apolipoprotein C-III (ApoC-III) is a widely known player in triglyceride metabolism, and it has been recently recognized as a polyhedric factor which may regulate several pathways beyond lipid metabolism by influencing cardiovascular, metabolic, and neurological disease risk. This review summarizes the different functions of ApoC-III and underlines the recent findings related to its multifaceted pathophysiological role.

Recent findings

The role of ApoC-III has been implicated in HDL metabolism and in the development of atherosclerosis, inflammation, and ER stress in endothelial cells. ApoC-III has been recently considered an important player in insulin resistance mechanisms, lipodystrophy, diabetic dyslipidemia, and postprandial hypertriglyceridemia (PPT).

SUBMITTER: Giammanco A 

PROVIDER: S-EPMC9947064 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature