Chromium-catalyzed stereodivergent E- and Z-selective alkyne hydrogenation controlled by cyclic (alkyl)(amino)carbene ligands.

ABSTRACT: The hydrogenation of alkynes allows the synthesis of olefins, which are important feedstock for the materials, pharmaceutical, and petrochemical industry. Thus, methods that enable this transformation via low-cost metal catalysis are desirable. However, achieving stereochemical control in this reaction is a long-standing challenge. Here, we report on the chromium-catalyzed E- and Z-selective olefin synthesis via hydrogenation of alkynes, controlled by two carbene ligands. A cyclic (alkyl)(amino)carbene ligand that contains a phosphino anchor enables the hydrogenation of alkynes in a trans-addition manner, selectively forming E-olefins. With an imino anchor-incorporated carbene ligand, the stereoselectivity can be switched, giving mainly Z-isomers. This ligand-enabled geometrical stereoinve

SUBMITTER: Ling L 

PROVIDER: S-EPMC9947122 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature