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Five new limonoids isolated from Walsura robusta.

ABSTRACT: Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1-4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480.

SUBMITTER: Hou L

PROVIDER: S-EPMC9947198 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Five new limonoids isolated from Walsura robusta.

Hou Li L Mei Cui-Xuan CX Yuan Chun-Mao CM Tang Gui-Hua GH Chen Duo-Zhi DZ Zhao Qing Q He Hong-Ping HP Cao Ming-Ming MM Hao Xiao-Jiang XJ

Natural products and bioprospecting 20230223 1

Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1-4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) were isolated from the leaves of Walsura robusta. Their structures were elucidated by NMR and MS data. Especially, the absolute configuration of toonapubesic acid B (6) was confirmed by X-ray diffraction study. Compounds 1-6 exhibited good cytotoxicity against the cancer cell lines HL-60, ...[more]

PMID: 36813988

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