Causal association between cardiovascular diseases and erectile dysfunction, a Mendelian randomization study.

ABSTRACT:

Background

Cardiovascular diseases (CVD), including coronary heart disease (CHD), heart failure, ischemic heart disease (IHD), and atrial fibrillation, are prevalent in the aged. However, the influence of CVD on ED is less investigated. This study was performed to clarify the causal association between CVD and ED.

Materials and methods

Genome-wide association studies (GWAS) datasets targeting CHD, heart failure, IHD, and atrial fibrillation were downloaded to retrieve single nucleotide polymorphisms (SNPs). Further, single-variable Mendelian randomization and multivariable Mendelian randomization (MVMR) were adopted to explore the causal association between CVD and ED.

Results

Genetically predicted CHD and heart failure were found to increase the risks of ED (OR = 1.0

SUBMITTER: Li Q 

PROVIDER: S-EPMC9947236 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature