Mitochondrial gene expression signature predicts prognosis of pediatric acute myeloid leukemia patients.

ABSTRACT:

Introduction

Gene expression profile of mitochondrial-related genes is not well deciphered in pediatric acute myeloid leukaemia (AML). We aimed to identify mitochondria-related differentially expressed genes (DEGs) in pediatric AML with their prognostic significance.

Methods

Children with de novo AML were included prospectively between July 2016-December 2019. Transcriptomic profiling was done for a subset of samples, stratified by mtDNA copy number. Top mitochondria-related DEGs were identified and validated by real-time PCR. A prognostic gene signature risk score was formulated using DEGs independently predictive of overall survival (OS) in multivariable analysis. Predictive ability of the risk score was estimated along with external validation in The Tumor Genome A

SUBMITTER: Chaudhary S 

PROVIDER: S-EPMC9947241 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature