Ontology highlight
ABSTRACT:
SUBMITTER: Kale A
PROVIDER: S-EPMC9947246 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Kale Ajinath A Shelke Vishwadeep V Dagar Neha N Anders Hans-Joachim HJ Gaikwad Anil Bhanudas AB
Frontiers in pharmacology 20230209
Antiviral drugs such as Remdesivir (Veklury), Nirmatrelvir with Ritonavir (Paxlovid), Azvudine, and Molnupiravir (Lagevrio) can reduce the risk for severe and fatal Coronavirus Disease (COVID)-19. Although chronic kidney disease is a highly prevalent risk factor for severe and fatal COVID-19, most clinical trials with these drugs excluded patients with impaired kidney function. Advanced CKD is associated with a state of secondary immunodeficiency (SIDKD), which increases the susceptibility to se ...[more]