Anti-angiogenic collagen IV-derived peptide target engagement with α_vβ₃ and α₅β₁ in ocular neovascularization models.

ABSTRACT: AXT107, a collagen-derived peptide that binds integrins α_vβ₃ and α₅β₁ with high affinity, suppresses vascular endothelial growth factor (VEGF) signaling, promotes angiopoietin 2-induced Tie2 activation, and suppresses neovascularization (NV) and vascular leakage. Immunohistochemical staining for α_vβ₃ and α₅β₁ was markedly increased in NV compared with normal retinal vessels. After intravitreous injection of AXT107, there was no staining with an anti-AXT107 antibody on normal vessels but robust staining of NV that co-localized with α_vβ₃ and α₅β₁. Likewise, after intravitreous injection, fluorescein amidite-labeled AXT107 co-localized with α_vβ_3</

SUBMITTER: Lima E Silva R 

PROVIDER: S-EPMC9947312 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature