Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is the leading cause of dementia worldwide, but its pathophysiological phenomena are not fully elucidated. Many neurophysiological markers have been suggested to identify early cognitive impairments of AD. However, the diagnosis of this disease remains a challenge for specialists. In the present cross-sectional study, our objective was to evaluate the manifestations and mechanisms underlying visual-spatial deficits at the early stages of AD.

Methods

We combined behavioral, electroencephalography (EEG), and eye movement recordings during the performance of a spatial navigation task (a virtual version of the Morris Water Maze adapted to humans). Participants (69-88 years old) with amnesic mild cognitive impairment-Clinical Dementia Rating

SUBMITTER: Plaza-Rosales I 

PROVIDER: S-EPMC9947357 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature