Chrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity.

ABSTRACT:

Objective

Mucosal immunization was an effective defender against pathogens. Nasal vaccines could activate both systemic and mucosal immunity to trigger protective immune responses. However, due to the weak immunogenicity of nasal vaccines and the lack of appropriate antigen carriers, very few nasal vaccines have been clinically approved for human use, which was a major barrier to the development of nasal vaccines. Plant-derived adjuvants are promising candidates for vaccine delivery systems due to their relatively safe immunogenic properties. In particular, the distinctive structure of pollen was beneficial to the stability and retention of antigen in the nasal mucosa.

Methods

Herein, a novel wild-type chrysanthemum sporopollenin vaccine delivery system loaded with a w/o/w e

SUBMITTER: Liu J 

PROVIDER: S-EPMC9947463 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature