High-risk multiple myeloma predicted by circulating plasma cells and its genetic characteristics.

ABSTRACT:

Introduction

Circulating plasma cells (CPC) have been reported to be one of the indicators of high-risk multiple myeloma (MM), yet the prognostic significance of CPC in Chinese population and the genetic mechanisms underlying CPC formation have not been fully elucidated.

Methods

Patients with newly diagnosed MM were included in this study. We used multi-parameter flow cytometry (MFC) for CPC quantification and next-generation sequencing (NGS) technology for mutational landscape mapping to identify the correlation of CPC level with clinical characteristics and the mutations.

Results

A total of 301 patients were enrolled in this investigation. We demonstrated that CPC quantification could effectively mirror the tumor load, and CPC ≥ 0.105% at diagnosis or detectable CPC

SUBMITTER: Xia Y 

PROVIDER: S-EPMC9947848 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature