The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56^bright NK cells.

ABSTRACT: The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory receptor TIGIT decreases NK cell cytotoxicity and is involved in NK cell exhaustion, but has also been associated with liver regeneration, highlighting that the contribution of human intrahepatic CD56^bright NK cells in regulating tissue homeostasis remains incompletely understood. A targeted single-cell mRNA analysis revealed distinct transcriptional differences between matched human peripheral blood and intrahepatic CD56^bright NK cells. Multiparameter flow cytometry identified a cluster of intrahepatic NK cells with overlapping high expression of CD56, CD69, CXCR6, TIGIT and CD96. Intrahepat

SUBMITTER: Ziegler AE 

PROVIDER: S-EPMC9948018 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature