Sinusoidal CO₂ respiratory challenge for concurrent perfusion and cerebrovascular reactivity MRI.

ABSTRACT: Introduction: Deoxygenation-based dynamic susceptibility contrast (dDSC) has previously leveraged respiratory challenges to modulate blood oxygen content as an endogenous source of contrast alternative to gadolinium injection in perfusion-weighted MRI. This work proposed the use of sinusoidal modulation of end-tidal CO₂ pressures (SineCO ₂ ), which has previously been used to measure cerebrovascular reactivity, to induce susceptibility-weighted gradient-echo signal loss to measure brain perfusion. Methods: SineCO ₂ was performed in 10 healthy volunteers (age 37 ± 11, 60% female), and tracer kinetics model was applied in the frequency domain to calculate cerebral blood flow, cerebral blood volume, mean transit time,

SUBMITTER: Vu C 

PROVIDER: S-EPMC9948030 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature