Bacillus subtilis vector based oral rabies vaccines induced potent immune response and protective efficacy in mice.

ABSTRACT:

Introduction

Rabies is a worldwide epidemic that poses a serious threat to global public health. At present, rabies in domestic dogs, cats, and some pets can be effectively prevented and controlled by intramuscular injection of rabies vaccine. But for some inaccessible animals, especially stray dogs, and wild animals, it is difficult to prevent with intramuscular injection. Therefore, it is necessary to develop a safe and effective oral rabies vaccine.

Methods

We constructed recombinant Bacillus subtilis (B. subtilis) expressing two different strains of rabies virus G protein, named CotG-E-G and CotG-C-G, immunogenicity was studied in mice.

Results

The results showed that CotG-E-G and CotG-C-G could significantly increase the specific SIgA titers in fece

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9948087 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature