Colonization resistance is dispensable for segregation of oral and gut microbiota.

ABSTRACT:

Background

The oral and colonic microbiota are distinct in healthy individuals. However, this distinction is diminished in common diseases such as colon cancer and inflammatory bowel disease, suggesting a potential pathogenic role for oral bacteria when ectopically colonized in the gut. A key mechanism for the segregation of oral and colonic microbiota niches is thought to be microbiota-mediated colonization resistance whereby the commensal gut microbiota outcompete and eliminate the ingested oral bacteria.

Methods

We tested this theory by analyzing exact amplicon sequence variants generated from concurrent fecal and oral samples from healthy volunteers exposed to a brief course of a single antibiotic (cohort 1), acute leukemia patients (cohort 2), and stem cell transplant r

SUBMITTER: Rashidi A 

PROVIDER: S-EPMC9948407 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature