Feto-placental endothelial dysfunction in Gestational Diabetes Mellitus under dietary or insulin therapy.

ABSTRACT:

Objective

Gestational diabetes mellitus (GDM) is a serious complication in pregnancy. Despite controlling the plasma glucose levels with dietary intervention (GDM-D) or insulin therapy (GDM-I), children born of diabetic mothers suffer more long-term complications from childhood to early adulthood. Placental circulation and nutrient exchange play a vital role in fetal development. Additionally, placental endothelial function is an indicator of vascular health, and plays an important role in maintaining placental circulation for nutrient exchange. This study was conducted to assess changes in fetal endothelial dysfunction in GDM under different interventions during pregnancy.

Methods

The primary human umbilical vein endothelial cells (HUVECs) were obtained from normal pregnant

SUBMITTER: Wang JJ 

PROVIDER: S-EPMC9948408 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature