Kruppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis.

ABSTRACT:

Background

Circadian disruption is an emerging driver of breast cancer (BCa), with epidemiological studies linking shift work and chronic jet lag to increased BCa risk. Indeed, several clock genes participate in the gating of mitotic entry, regulation of DNA damage response, and epithelial-to-mesenchymal transition, thus impacting BCa etiology. Dysregulated estrogen (17β-estradiol, E2) and glucocorticoid (GC) signaling prevalent in BCa may further contribute to clock desynchrony by directly regulating the expression and cycling dynamics of genes comprising the local breast oscillator. In this study, we investigated the tumor suppressor gene, Krüppel-like factor 9 (KLF9), as an important point of crosstalk between hormone signaling and the circadian molecular network, and further ex

SUBMITTER: Ybanez WS 

PROVIDER: S-EPMC9948451 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature