Identification and validation of a novel prognostic signature based on mitochondria and oxidative stress related genes for glioblastoma.

ABSTRACT:

Background

Mitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase in ROS content is the primary cause of oxidative stress, which plays an important role in tumor proliferation, invasion, angiogenesis, and treatment. However, the relationship between mitochondrial oxidative stress-related genes and glioblastoma (GBM) remains unclear. This study aimed to investigate the value of mitochondria and oxidative stress-related genes in the prognosis and therapeutic targets of GBM.

Methods

We retrieved mitochondria and oxidative stress-related genes from several public databases. The LASSO regression and Cox analyses were utilized to build a risk model and the ROC curve was used to assess its performance. Then, we analyzed the correlat

SUBMITTER: Tong S 

PROVIDER: S-EPMC9948483 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature