Thyroid hormone receptor knockout prevents the loss of Xenopus tail regeneration capacity at metamorphic climax.

ABSTRACT:

Background

Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even entire body to full function. Studies in mammals have revealed that many organs lose regenerative ability soon after birth when thyroid hormone (T3) level is high. This suggests that T3 play an important role in organ regeneration. Intriguingly, plasma T3 level peaks during amphibian metamorphosis, which is very similar to postembryonic development in humans. In addition, many organs, such as heart and tail, also lose their regenerative ability during metamorphosis. These make frogs as a good model to address how the organs gradually lose their regenerative ability during development and what roles T3 may play in this. Early tail regeneration studies h

SUBMITTER: Wang S 

PROVIDER: S-EPMC9948486 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature